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KMID : 0377619930580100703
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Korean Jungang Medical Journal
1993 Volume.58 No. 10 p.703 ~ p.708
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Effect of Exercise and Nutrition on Blood Pressure Serum Lipids and Life-Span of Stroke-Prone Spontaneously Hypertensive Rat (SHRSP)
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Lim Soon-Gill
Yukio Yamori
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Abstract
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In this study we investigated the effect of exercise and nutrition on blood pressure, serum lip ids and life-span in stroke-prone spontaneously hypertensive rats (SHRSP). The results were as follows:
For the normal diet (SP rats, body weight in both the forced exercise and voluntary exercise conditions were generally lower than those in the control group. In regard to the HFC rats as well, the exercise groups showed clearly lower body weights than the control group. For the high fat diet rats (HFC) who did not exercise, body weight increased considerably, but it was shown that weight gain was suppressed according to amount of exercise. As for blood pressure, in the exercise groups both the SP and HFC diet groups showed slightly lower rates than those of the control group. According to diet, the HFC groups showed significantly lower rates than the SP groups (from 3 to 7 weeks p < 0.01, from 9~12 weeks p < 0.05). In this experiment it was shown that a high fat diet acted to suppress the increase of blood pressure.
As for serum triglyceride, in the SP diet groups the exercise conditions showed slightly lower levels than inthe control. Also the SP groups showed significantly lower levels than the HFC groups (p < 0.05). As for serum total cholesterol, the HFC diet groups showed significantly greater increases than the SP groups (p < 0.01). Maintaining a slightly high level of serum total cholesterol is thought to be effective in preventing the occurrence of cerebral apoplexy and high blood pressure. As for phospholipids, the exercise groups showed higher levels than the control. Furthermore, the SP diet groups showed clearly higher levels than the HFC groups. As for free fatty acids, the exercise groups showed higher rates than the control group in both SP and HFC diet conditions. In regard to differences according to diet, the HFC groups showed higher rates than the SP groups.
In regard to life-span, among ´the SP diet groups, the average in the voluntary exercise condition was 117 days and in the forced exercise condition was 99 days. Broken down according to diet, for the SP groups it was 105 days and for the HFC groups it was 160 days. This shows a significant extension of life for the HFC groups (p < 0.01).
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